The reality TV star will assist presenters and help to hand out trophies at the Golden Globe Awards ceremony on 13 January (13).
Eastwood says, ""I have watched the Golden Globes ceremonies since I was a little girl, and it means so much to me to be a part of one of Hollywood's most illustrious events.""
Hollywood Foreign Press Association president Dr. Aida Takla-O'Reilly adds, ""Francesca comes from a very talented family and we are delighted to have her be our Miss Golden Globe. She is a budding actress and is a great addition as we celebrate the show's 70th anniversary.""
The honour is bestowed by members of the Hollywood Foreign Press Association, the organisation behind the Golden Globes, and the role is traditionally handed to the child of a celebrity.
Francesca follows in the footsteps of her half-sister, Kathryn Eastwood, who was Miss Golden Globe in 2005.
Others to have previously filled the role include Bruce Willis' daughter Rumer, Lorraine Nicholson, whose father is Hollywood superstar Jack Nicholson, and Kevin Costner's daughter Lily.