The Bridget Jones's Diary star has co-written Cinnamon Girl, about four women who come of age in Los Angeles during the 1960s and '70s.
The plot features similarities to Zellweger's own journey from Texas to Hollywood, and as well as helping create the script, she will take on the role of executive producer.
The show will air on America's Lifetime network, which broadcast Zellweger's producing debut, TV movie Living Proof, in 2008.
Lifetime president Nancy Dubuc says, ""Renee's passion, clarity of character and deep emotion for this project immediately transported us to the late '60s/early '70s and created a resonance with us wanting to relive that energy.
""Cinnamon Girl is a game changer for our network and is exactly the type of show we want to deliver.""